I'm trying out Safari right now. The only things I miss from Firefox are Adblock and Del.icio.us.
Another thing that bothers me is that I haven't figured out a good shortcut to go to the search box. Safari uses Command-Option-F, an 3-key, 1-handed chord. In Firefox it was simply Command-K. For now, I'm using Command-L to go to the Address Bar and then Tab to go to the search box.
Ok, now I'm missing being able to search for and click on links using foreward-slash search.